Genome Editing in Large Animals

Genome Editing



Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...

Genome Editing Tools in Plants

Genome editing tools have the potential to change the genomic architecture of a genome at precise locations, with desired accuracy. These tools have been efficiently used for trait discovery and for the generation of plants with high crop yields and resistance to biotic and abiotic stresses. Due to complex genomic architecture, it is challenging to edit all of the genes/genomes using a particul...

From Gene Targeting to Genome Editing: Transgenic animals applications and beyond.

Genome modification technologies are powerful tools for molecular biology and related areas. Advances in animal transgenesis and genome editing technologies during the past three decades allowed systematic interrogation of gene function that can help model how the genome influences cellular physiology. Genetic engineering via homologous recombination (HR) has been the standard method to modify ...

Editing Large OWL Ontologies

Over the last few years, ontologies became a cornerstone of many areas of computer science, the most prominent example being the semantic web. Ontologies will usually be developed by people who are not experts in knowledge representation. Moreover, in many use cases, the ontologies will be very large. Thus, it is essential to provide easyto-understand browsing and editing tools for very large o...